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LinfoVir® Gola spray

LinfoVir® Gola spray is a food supplement made up of natural components, useful for encouraging the natural immune defenses and the well being of your throat, particularly during the cold season.

LinfoVir® Gola spray contains resveratrol, beta-glucan, zinc, aloe vera and hyaluronic acid, which thank to their well known properties as antiviral, anti-inflammatory, antioxidant and hydrating of the mucosa, can help to alleviate, since the first manifestation, the most common symptoms of acute pharyngitis:

  • throat itching
  • rough and scratchy throat
  • painful swallowing
  • dryness

Package: 30 ml bottle with oral spray.

How to use: 4-5 sprays into the throat 3 or 4 times per day.

Warnings: It is recommended to shake well before use. Do not exceed the recommended daily dose. Excessive consumption may have laxative effects. Do not inhale.

RESVERATROL BIBLIOGRAPHY

Cottart CH, Nivet-Antoine V, Laguillier-Morizot C, Beaudeux JL. Resveratrol bioavailability and toxicity in humans. Mol Nutr Food Res, 2010;54(1):7-16.

Berardi V, Ricci F, Castelli M, Galati G, Risuleo G. Resveratrol exhibits a strong cytotoxic activity in cultured cells and has an antiviral action against polyomavirus: potential clinical use. J Exp Clin Cancer Res, 2009;28:96.

Drago L, Nicola L, Ossola F, De Vecchi E. In vitro antiviral activity of resveratrol against respiratory viruses. J Chemother, 2008;20:393-394.

Candelario-Jalil E, Pinheiro de Oliveira AC, Gräf S, Bhatia HS, Hüll M, Muñoz E, Fiebich BL. Resveratrol potently reduces prostaglandin E2 production and free radical formation in lipopolysaccharide-activated primary rat microglia. J Neuroinflammation, 2007;4:25.

Kasdallah-Grissa A, Mornagui B, Aouani E, Hammami H, Gharbi N, Kamoun A, El-Fazaa S. Protective effect of resveratrol on ethanol-induced lipid peroxidation in rats. Alcohol & Alcoholism, 2006;41(3):236-9.

Palamara AT, Nencioni L, Aquilano K, De Chiara G, Hernandez L, Cozzolino F, Ciriolo MR, Garaci E. Inhibition of influenza A virus replication by resveratrol. J Infect Dis, 2005;191:1719-1729.

Wang LX, Heredia A, Song H, Zhang Z, Yu B, Davis C, Redfield R. Resveratrol glucuronides as the metabolites of resveratrol in humans: characterization, synthesis, and anti-HIV activity. J Pharm Sci, 2004;93:2448-2457.

Juan ME, Vinardell MP, Planas JM. The daily oral administration of high doses of trans-resveratrol to rats for 28 days is not harmful. J Nutr, 2002;132(2):257-60.

Bastianetto S, Zheng WH, Quirion R. Neuroprotective abilities of resveratrol and other red wine constituents against nitric oxide-related toxicity in cultured hippocampal neurons. Br J Pharmacol, 2000;131(4):711-20.

Tsai SH, Lin-Shiau SY, Lin JK. Suppression of nitric oxide synthase and the down-regulation of the activation of NF-kB in macrophages by resveratrol. British J Pharmacol, 1999;126:673-680.

Ragione FD, Cucciolla V, Borriello A, Pietra VD, Racioppi L, Soldati G, Manna C, Galletti P, Zappia V. Resveratrol arrests the cell division cycle at S/G2 phase transition. Biochem Biophys Res Commun, 1998;250:53-58.


BETA-GLUCAN BIBLIOGRAPHY

Saluk-Juszczak J, Krolewska K, Wachowicz B. Beta-glucan from Saccharomyces cerevisiae as a blood platelet antioxidant. Platelets, 2010;21(6):451-9.

Kogan G, Pajtinka M, Babincova M, Miadokova E, Rauko P, Slamenova D, Korolenko TA. Yeast cell wall polysaccharides as antioxidants and antimutagens: can they fight cancer? Neoplasma, 2008;55:387-93.

Novak M, Vetvicka V. Beta-glucans, history, and the present: immunomodulatory aspects and mechanisms of action. J Immunotoxicol, 2008;5(1):47-57.

Cerci C, Yildirim M, Ceyhan M, Bozkurt S, Doguc D, Gokicimen A. The effects of topical and systemic beta glucan administration on wound healing impaired by corticosteroids. Wounds, 2008;20:341-346.

Vetvicka V, Volny T, Saraswat-Ohri S, Vashishta A, Vancikova Z, Vetvickova J. Glucan and resveratrol complex – possible synergistic effects on immune system. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub, 2007;151:41-46.

Hong F, Yan J, Baran JT, Allendorf DJ, Hansen RD, Ostroff GR, Xing PX, Cheung NK, Ross GD. Mechanism by which orally administered beta-1,3-glucans enhance the tumoricidal activity of antitumor monoclonal antibodies in murine tumor models. J Immunol, 2004;173:797-806.

Hong F, Hansen RD, Yan J, Allendorf DJ, Baran JT, Ostroff GR, Ross GD. Beta-glucan functions as an adjuvant for monoclonal antibody immunotherapy by recruiting tumoricidal granulocytes as killer cells. Cancer Res, 2003;63:9023-31.

Cleary JA, Kelly GE, Husband AJ. The effect of molecular weight and beta-1,6-linkages on priming of macrophage function in mice by (1,3)-beta-D-glucan. Immunol Cell Biol, 1999;77:395-403.

Babineau TJ, Hackford A, Kenler A, Bistrian B, Forse RA, Fairchild PG, Heard S, Keroack M, Caushaj P, Benotti P. A phase II multicenter, double-blind, randomized, placebo-controlled study of three dosages of an immunomodulator (PGG-glucan) in high-risk surgical patients. Arch Surg, 1994;129:1204-10.

Browder W, Williams D, Pretus H, Olivero G, Enrichens F, Mao P, Franchello A. Beneficial effect of enhanced macrophage function in the trauma patient. Ann Surg, 1990;211:605-12.


ZINC BIBLIOGRAPHY

Suara RO, Crowe JE Jr. Effect of zinc salts on respiratory syncytial virus replication. Antimicrob Agents Chemother, 2004;48(3):783-90.

Eby GA. Treatment of croup with topical ionic zinc. Med Hypotheses, 2010 Mar;74(3):614.

Mossad SB. Effect of zincum gluconicum nasal gel on the duration and symptom severity of the common cold in otherwise healthy adults.QJM, 2003;96:35-43.


ALOE VERA BIBLIOGRAPHY

Joseph B, Raj SJ. Pharmacognostic and phytochemical properties of aloe vera linn – an overview. Volume 4, Issue 2, September – October 2010; Article 017 ISSN 0976 – 044X.

Langmead L, Makins RJ, Rampton DS. Anti-inflammatory effects of aloe vera gel in human colorectal mucosa in vitro. Aliment Pharmacol Ther, 2004;19(5):521-7.

Park MY, Kwon HJ, Sung MK. Dietary aloin, aloesin, or aloe-gel exerts anti-inflammatory activity in a rat colitis model. Life Sci, 2011;88(11-12):486-92.

Das S, Mishra B, Gill K, Ashraf MS, Singh AK, Sinha M, Sharma S, Xess I, Dalal K, Singh TP, Dey S. Isolation and characterization of novel protein with anti-fungal and anti-inflammatory properties from Aloe vera leaf gel. Int J Biol Macromol, 2011;48(1):38-43.