Novità 2012



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Linfoflu® A

Linfoflu® A bustine è stato attentamente formulato per rispondere alle esigenze nutrizionali del bambino in età scolare, soggetto a stress psicofisico ed immunologico.
Lo stress e la cattiva alimentazione, infatti, possono compromettere il sistema immunitario del bambino, producendo così una serie di effetti come l'aumento di infezioni respiratorie, raffreddori comuni e forme influenzali.
Linfoflu® A contiene Beta-glucano, Resveratrolo, Zinco e Vitamina A, in una formulazione unica, che grazie alle ben note proprietà immunostimolanti, antivirali e antiossidanti dei suoi componenti può risultare utile nel favorire le naturali difese organiche.

Linfoflu® A ha un sapore di amarena molto gradito al bambino e può essere associato ad antibiotici o altri trattamenti in corso.

Confezione disponibile in farmacia: 12 bustine di granulato effervescente.

Modo d’uso: Si consiglia una bustina al giorno sciolta in mezzo bicchiere d’acqua lontano dai pasti.

Avvertenze: Gli integratori non vanno intesi quali sostituti di una dieta variata e di un sano stile di vita. Non eccedere le dosi consigliate. Tenere fuori dalla portata dei bambini di età inferiore ai tre anni. Conservare in luogo fresco e asciutto. Contiene una fonte di fenilalanina.

BIBLIOGRAFIA RESVERATROLO

Cottart CH, Nivet-Antoine V, Laguillier-Morizot C, Beaudeux JL. Resveratrol bioavailability and toxicity in humans. Mol Nutr Food Res, 2010;54(1):7-16.

Berardi V, Ricci F, Castelli M, Galati G, Risuleo G. Resveratrol exhibits a strong cytotoxic activity in cultured cells and has an antiviral action against polyomavirus: potential clinical use. J Exp Clin Cancer Res, 2009;28:96.

Drago L, Nicola L, Ossola F, De Vecchi E. In vitro antiviral activity of resveratrol against respiratory viruses. J Chemother, 2008;20:393-394.

Candelario-Jalil E, Pinheiro de Oliveira AC, Gräf S, Bhatia HS, Hüll M, Muñoz E, Fiebich BL. Resveratrol potently reduces prostaglandin E2 production and free radical formation in lipopolysaccharide-activated primary rat microglia. J Neuroinflammation, 2007;4:25.

Kasdallah-Grissa A, Mornagui B, Aouani E, Hammami H, Gharbi N, Kamoun A, El-Fazaa S. Protective effect of resveratrol on ethanol-induced lipid peroxidation in rats. Alcohol & Alcoholism, 2006;41(3):236-9.

Pietraforte D. Antiossidanti polifenolici della dieta nella prevenzione delle patologie degenerative. 2005. ISS, rapporti ISTISAN 05/40.

Palamara AT, Nencioni L, Aquilano K, De Chiara G, Hernandez L, Cozzolino F, Ciriolo MR, Garaci E. Inhibition of influenza A virus replication by resveratrol. J Infect Dis, 2005;191:1719-1729.

Wang LX, Heredia A, Song H, Zhang Z, Yu B, Davis C, Redfield R. Resveratrol glucuronides as the metabolites of resveratrol in humans: characterization, synthesis, and anti-HIV activity. J Pharm Sci, 2004;93:2448-2457.

Juan ME, Vinardell MP, Planas JM. The daily oral administration of high doses of trans-resveratrol to rats for 28 days is not harmful. J Nutr, 2002;132(2):257-60.

Bastianetto S, Zheng WH, Quirion R. Neuroprotective abilities of resveratrol and other red wine constituents against nitric oxide-related toxicity in cultured hippocampal neurons. Br J Pharmacol, 2000;131(4):711-20.

Tsai SH, Lin-Shiau SY, Lin JK. Suppression of nitric oxide synthase and the down-regulation of the activation of NF-kB in macrophages by resveratrol. British J Pharmacol, 1999;126:673-680.

Ragione FD, Cucciolla V, Borriello A, Pietra VD, Racioppi L, Soldati G, Manna C, Galletti P, Zappia V. Resveratrol arrests the cell division cycle at S/G2 phase transition. Biochem Biophys Res Commun, 1998;250:53-58.


BIBLIOGRAFIA BETA-GLUCANO

Saluk-Juszczak J, Krolewska K, Wachowicz B. Beta-glucan from Saccharomyces cerevisiae as a blood platelet antioxidant. Platelets, 2010;21(6):451-9.

Kogan G, Pajtinka M, Babincova M, Miadokova E, Rauko P, Slamenova D, Korolenko TA. Yeast cell wall polysaccharides as antioxidants and antimutagens: can they fight cancer? Neoplasma, 2008;55:387-93.

Novak M, Vetvicka V. Beta-glucans, history, and the present: immunomodulatory aspects and mechanisms of action. J Immunotoxicol, 2008;5(1):47-57.

Cerci C, Yildirim M, Ceyhan M, Bozkurt S, Doguc D, Gokicimen A. The effects of topical and systemic beta glucan administration on wound healing impaired by corticosteroids. Wounds, 2008;20:341-346.

Vetvicka V, Volny T, Saraswat-Ohri S, Vashishta A, Vancikova Z, Vetvickova J. Glucan and resveratrol complex – possible synergistic effects on immune system. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub, 2007;151:41-46.

Hong F, Yan J, Baran JT, Allendorf DJ, Hansen RD, Ostroff GR, Xing PX, Cheung NK, Ross GD. Mechanism by which orally administered beta-1,3-glucans enhance the tumoricidal activity of antitumor monoclonal antibodies in murine tumor models. J Immunol, 2004;173:797-806.

Hong F, Hansen RD, Yan J, Allendorf DJ, Baran JT, Ostroff GR, Ross GD. Beta-glucan functions as an adjuvant for monoclonal antibody immunotherapy by recruiting tumoricidal granulocytes as killer cells. Cancer Res, 2003;63:9023-31.

Cleary JA, Kelly GE, Husband AJ. The effect of molecular weight and beta-1,6-linkages on priming of macrophage function in mice by (1,3)-beta-D-glucan. Immunol Cell Biol, 1999;77:395-403.

Babineau TJ, Hackford A, Kenler A, Bistrian B, Forse RA, Fairchild PG, Heard S, Keroack M, Caushaj P, Benotti P. A phase II multicenter, double-blind, randomized, placebo-controlled study of three dosages of an immunomodulator (PGG-glucan) in high-risk surgical patients. Arch Surg, 1994;129:1204-10.

Browder W, Williams D, Pretus H, Olivero G, Enrichens F, Mao P, Franchello A. Beneficial effect of enhanced macrophage function in the trauma patient. Ann Surg, 1990;211:605-12.

BIBLIOGRAFIA ZINCO E VITAMINA A

Lazzerini M, Ronfani L. Oral zinc for treating diarrhoea in children. Cochrane Database Syst Rev, 2008;(3):CD005436.

Fischer Walker CL, Black RE. Micronutrients and Diarrheal Disease. Clin Infect Dis, 2007;45:S73-7.

Long KZ, Rosado JL, DuPont HL, Hertzmark E, Santos JI. Supplementation with vitamin A reduces watery diarrhoea and respiratory infections in Mexican children. Br J Nutr, 2007;97:337-43.

Long KZ, Montoya Y, Hertzmark E, Santos JI, Rosado JL. A double-blind, randomized, clinical trial of the effect of vitamin A and zinc supplementation on diarrheal disease and respiratory tract infections in children in Mexico City, Mexico. Am J Clin Nutr, 2006;83:693-700.

Ozturk Y, Buyukgebiz B, Arslan N, Ozer E, Lebe B. Serum vitamin A and total carotene concentrations in well-nourished children with Helicobacter pylori infection. J Pediatr Gastroenterol Nutr, 2003;36:502-4.

Jason J, Archibald LK, Nwanyanwu OC, Sowell AL, Buchanan I, Larned J, Bell M, Kazembe Peter N, Dobbie H, Jarvis WR. Vitamin A Levels and Immunity in Humans. Clin Diagn Lab Immunol, 2002;9:616-21.

Costello RB, Grumstrup-Scott J. Zinc: What role might supplements play? J Am Diet Assoc, 2000;100:371-75.

Fraker PJ, King LE, Laakko T, Vollmer TL. The dynamic link between the integrity of the immune system and zinc status. J Nutr, 2000;130:1399S-406S.

Allen LH. Zinc and micronutrient supplements for children. Am J Clin Nutr, 1998;68:495S-8S.

Bahl R, Bhandari N, Taneja S, Bhan MK. The impact of vitamin A supplementation on physical growth of children is dependent on season. Eur J Clin Nutr, 1997;51:26-9.

Fawzi WW, Herrera MG, Willett WC, Nestel P, el Amin A, Mohamed KA. The effect of vitamin A supplementation on the growth of preschool children in the Sudan. Am J Public Health, 1997;87:1359-62.