Linfoflu® sciroppo è un integratore alimentare contenente Beta-glucano, Resveratrolo, L-arginina, Zinco e Acido folico. Queste sostanze possono essere carenti nell’organismo di alcuni bambini che manifestano una elevata frequenza di infezioni alle alte vie respiratorie. Le infezioni, quali rinite, adenoidite, tonsillite, faringite, accompagnate spesso da otite catarrale, provocano disturbi respiratori del sonno, costringono il bambino a respirare con la bocca, rendono il bambino astenico ed inappetente.

Linfoflu® ha un sapore di amarena molto gradito al bambino e può essere associato ad antibiotici o altri trattamenti in corso.

Confezione disponibile in farmacia: flacone da 120 ml con misurino graduato a 5-10 ml.

Modo d'uso
In prevenzione: un misurino da 5 ml al mattino lontano dai pasti per tre mesi.
Nelle fasi acute: nei primi tre giorni, un misurino da 5 ml mattino e sera lontano dai pasti. Nei giorni successivi, un misurino da 5 ml al mattino fino ad esaurimento del flacone.

Avvertenze: Il colore dello sciroppo è rosso intenso, tuttavia eventuali cambiamenti di colore, che si possono verificare in relazione all’utilizzo di sostanze naturali, non compromettono la validità del prodotto. Si consiglia di conservare il flacone ben chiuso in un luogo fresco.

BIBLIOGRAFIA RESVERATROLO

Cottart CH, Nivet-Antoine V, Laguillier-Morizot C, Beaudeux JL. Resveratrol bioavailability and toxicity in humans. Mol Nutr Food Res, 2010;54(1):7-16.

Berardi V, Ricci F, Castelli M, Galati G, Risuleo G. Resveratrol exhibits a strong cytotoxic activity in cultured cells and has an antiviral action against polyomavirus: potential clinical use. J Exp Clin Cancer Res, 2009;28:96.

Drago L, Nicola L, Ossola F, De Vecchi E. In vitro antiviral activity of resveratrol against respiratory viruses. J Chemother, 2008;20:393-394.

Candelario-Jalil E, Pinheiro de Oliveira AC, Gräf S, Bhatia HS, Hüll M, Muñoz E, Fiebich BL. Resveratrol potently reduces prostaglandin E2 production and free radical formation in lipopolysaccharide-activated primary rat microglia. J Neuroinflammation, 2007;4:25.

Kasdallah-Grissa A, Mornagui B, Aouani E, Hammami H, Gharbi N, Kamoun A, El-Fazaa S. Protective effect of resveratrol on ethanol-induced lipid peroxidation in rats. Alcohol & Alcoholism, 2006;41(3):236-9.

Palamara AT, Nencioni L, Aquilano K, De Chiara G, Hernandez L, Cozzolino F, Ciriolo MR, Garaci E. Inhibition of influenza A virus replication by resveratrol. J Infect Dis, 2005;191:1719-1729.

Wang LX, Heredia A, Song H, Zhang Z, Yu B, Davis C, Redfield R. Resveratrol glucuronides as the metabolites of resveratrol in humans: characterization, synthesis, and anti-HIV activity. J Pharm Sci, 2004;93:2448-2457.

Juan ME, Vinardell MP, Planas JM. The daily oral administration of high doses of trans-resveratrol to rats for 28 days is not harmful. J Nutr, 2002;132(2):257-60.

Bastianetto S, Zheng WH, Quirion R. Neuroprotective abilities of resveratrol and other red wine constituents against nitric oxide-related toxicity in cultured hippocampal neurons. Br J Pharmacol, 2000;131(4):711-20.

Tsai SH, Lin-Shiau SY, Lin JK. Suppression of nitric oxide synthase and the down-regulation of the activation of NF-kB in macrophages by resveratrol. British J Pharmacol, 1999;126:673-680.

Ragione FD, Cucciolla V, Borriello A, Pietra VD, Racioppi L, Soldati G, Manna C, Galletti P, Zappia V. Resveratrol arrests the cell division cycle at S/G2 phase transition. Biochem Biophys Res Commun, 1998;250:53-58.


BIBLIOGRAFIA BETA-GLUCANO

Saluk-Juszczak J, Krolewska K, Wachowicz B. Beta-glucan from Saccharomyces cerevisiae as a blood platelet antioxidant. Platelets, 2010;21(6):451-9.

Kogan G, Pajtinka M, Babincova M, Miadokova E, Rauko P, Slamenova D, Korolenko TA. Yeast cell wall polysaccharides as antioxidants and antimutagens: can they fight cancer? Neoplasma, 2008;55:387-93.

Novak M, Vetvicka V. Beta-glucans, history, and the present: immunomodulatory aspects and mechanisms of action. J Immunotoxicol, 2008;5(1):47-57.

Cerci C, Yildirim M, Ceyhan M, Bozkurt S, Doguc D, Gokicimen A. The effects of topical and systemic beta glucan administration on wound healing impaired by corticosteroids. Wounds, 2008;20:341-346.

Vetvicka V, Volny T, Saraswat-Ohri S, Vashishta A, Vancikova Z, Vetvickova J. Glucan and resveratrol complex – possible synergistic effects on immune system. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub, 2007;151:41-46.

Hong F, Yan J, Baran JT, Allendorf DJ, Hansen RD, Ostroff GR, Xing PX, Cheung NK, Ross GD. Mechanism by which orally administered beta-1,3-glucans enhance the tumoricidal activity of antitumor monoclonal antibodies in murine tumor models. J Immunol, 2004;173:797-806.

Hong F, Hansen RD, Yan J, Allendorf DJ, Baran JT, Ostroff GR, Ross GD. Beta-glucan functions as an adjuvant for monoclonal antibody immunotherapy by recruiting tumoricidal granulocytes as killer cells. Cancer Res, 2003;63:9023-31.

Cleary JA, Kelly GE, Husband AJ. The effect of molecular weight and beta-1,6-linkages on priming of macrophage function in mice by (1,3)-beta-D-glucan. Immunol Cell Biol, 1999;77:395-403.

Babineau TJ, Hackford A, Kenler A, Bistrian B, Forse RA, Fairchild PG, Heard S, Keroack M, Caushaj P, Benotti P. A phase II multicenter, double-blind, randomized, placebo-controlled study of three dosages of an immunomodulator (PGG-glucan) in high-risk surgical patients. Arch Surg, 1994;129:1204-10.

Browder W, Williams D, Pretus H, Olivero G, Enrichens F, Mao P, Franchello A. Beneficial effect of enhanced macrophage function in the trauma patient. Ann Surg, 1990;211:605-12.